The side effects of Masteron will always include natural testosterone suppression in all men who supplement. Due to natural suppression, in order to avoid a low testosterone condition all men are encouraged to include exogenous testosterone into their plan. This will ensure a low level state doesn’t occur as the exogenous testosterone will provide your body with all it needs. If you do not include exogenous testosterone, you will open yourself up to all the low testosterone symptoms. If you do not include exogenous testosterone, even if you get away without experiencing low testosterone symptoms (rare but possible) keep in mind such a condition is extremely unhealthy and stressful to the body. Once the use of Masteron and all anabolic steroids has come to an end, natural testosterone production will begin again. In order to facilitate a smooth and strong recovery, most men are encouraged to implement a Post Cycle Therapy (PCT) program. A PCT program will often include the SERM’s Nolvadex ( Tamoxifen Citrate ) and Clomid ( Clomiphene Citrate ) and the powerful peptide hormone Human Chorionic Gonadotropin ( hCG ).
Masteron in particular may possibly exhibit even worse effects on the negative cholesterol changes it imparts on the human body. This is due to Masteron’s aromatase inhibiting and anti-estrogenic properties, as the reduction of Estrogen levels below normal physiological levels has been demonstrated in studies to impart an even worse impact on cholesterol profiles than when anabolic steroids are administered alone without an aromatase inhibitor. Testosterone in particular has demonstrated in one clinical study to have only a mild impact on HDL cholesterol after a 12 week period where 280mg of Testosterone Enanthate was administered weekly. The cholesterol profiles had later changed for the worse when an aromatase inhibitor was included, which resulted in a significant 25% drop in HDL cholesterol  . This must be remembered by any potential user of Masteron, and Estrogen levels must be closely monitored so as to ensure Masteron does not reduce Estrogen to the point whereby cholesterol profiles are impacted negatively.