Drostanolone propionate ( BAN ) (brand names Masteron , Drolban , others), also known as dromostanolone propionate ( USAN ), as well as 2α-methyl-4,5α-dihydrotestosterone , is a synthetic anabolic-androgenic steroid (AAS) and the propionate ester of drostanolone .   It is incapable of aromatization and has similar properties to dihydrotestosterone (DHT). [ citation needed ] It has been successfully used to treat breast cancer , but because of the high risk of virilization , options with better tolerability are usually prescribed instead.  Drostanolone propionate is not orally active , and must be administered instead via intramuscular injection . [ citation needed ]
In one small scale clinical trial of depressed patients, an improvement of symptoms which included anxiety, lack of drive and desire was observed.  In patients with dysthymia , unipolar , and bipolar depression significant improvement was observed.  In this series of studies, mesterolone lead to a significant decrease in LH and testosterone levels. In another study, 100 mg mesterolone cypionate was administered twice monthly. With regards to plasma T levels, there was no difference between the treated vs untreated group, and baseline LH levels were minimally affected.